IDENTIFICATION OF NOVEL TOXINS ASSOCIATED WITH THE EXTRACELLULAR CONTRACTILE INJECTION SYSTEM USING MACHINE LEARNING

Identification of novel toxins associated with the extracellular contractile injection system using machine learning

Abstract Secretion systems play a crucial role in microbe-microbe or host-microbe interactions.Among these systems, the extracellular contractile injection system (eCIS) is a unique bacterial and archaeal extracellular secretion system that injects protein toxins into target organisms.However, the specific proteins that eCISs inject into target cel

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Overexpression of miR-99a promoted expansion and suppressed differentiation of hematopoietic stem/progenitor cells

Abstract MicroRNAs (miRNAs) are a class of non-coding RNAs involved in a variety of pathophysiological processes.We have leather-collar previously reported that the abnormally high expression of miR-99a is associated with drug resistance and poor prognosis in acute myeloid leukemia.However, the impact of miR-99a on normal hematopoiesis is not well

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Characterization of chlorogenic acids (CGA) and nine isomers in an F2 population derived from Coffea arabica L.

Chlorogenic acids (CGA) and their isomers have been associated with sensory attributes of the coffee beverage such as acidity, astringency, and bitterness.They have been linked to coffee rust resistance and acknowledged as bioactive compounds due to their antioxidant power with benefits for human health.The total chlorogenic acids (TCGA) and nine i

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